Anticorps Monoclonal anti-CD357 (GITR)

CD357 (GITR) Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG2b, kappa

Réactivité testée

souris

Applications

FC

Conjugaison

FITC Fluorescent Dye

CloneNo.

DTA-1

N° de cat : FITC-65102

Synonymes

AITR, CD357, CD357 (GITR), Gitr, Tnfrsf18



Applications testées

Résultats positifs en cytométriesplénocytes de souris,

Dilution recommandée

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

FITC-65102 cible CD357 (GITR) dans les applications de FC et montre une réactivité avec des échantillons souris

Réactivité souris
Hôte / Isotype Rat / IgG2b, kappa
Clonalité Monoclonal
Type Anticorps
Immunogène Lymphocytes T CD25+ CD4+ de souris
Nom complet tumor necrosis factor receptor superfamily, member 18
Numéro d’acquisition GenBankBC146517
Symbole du gène Tnfrsf18
Identification du gène (NCBI) 21936
Conjugaison FITC Fluorescent Dye
Excitation/Emission maxima wavelengths498 nm / 526 nm
Forme Liquide
Méthode de purification Purification par affinité
Tampon de stockage Tampon à base de phosphate avec azoture de sodium à 0,09 % et gélatine à 0,1 %, pH 7,2.
Conditions de stockageStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Glucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552).

Protocole

Product Specific Protocols
FC protocol for FITC CD357 (GITR) antibody FITC-65102Download protocol
Standard Protocols
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