Anticorps Monoclonal anti-CD41

CD41 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG1, kappa

Réactivité testée

Humain, primates non humains

Applications

FC

Conjugaison

Non conjugué

CloneNo.

HIP8

N° de cat : 65173-1-Ig

Synonymes

CD41a, CD41B, GP2B, GPalpha IIb, GPIIb

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Galerie de données de validation

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  FC experiment of human peripheral blood using 65173-1-Ig

  100 ul human platelet rich plasma (diluted 1:4 with PBS) was surface stained with 0.2 ug Anti-Human CD41a (65173-1-Ig, Clone:HIP8) or Mouse IgG1 Isotype Control (65124-1-Ig, Clone: MOPC-21) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM005). Cells were not fixed.

• 

  FC experiment of human peripheral blood using 65173-1-Ig

  100 ul human platelet rich plasma (diluted 1:4 with PBS) was surface stained with 0.2 ug Anti-Human CD41a (65173-1-Ig, Clone:HIP8) or Mouse IgG1 Isotype Control (65124-1-Ig, Clone: MOPC-21) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM005). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: sang périphérique humain

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65173-1-Ig cible CD41 dans les applications de FC et montre une réactivité avec des échantillons Humain, primates non humains

• Réactivité: Humain, primates non humains
• Hôte / Isotype: Mouse / IgG1, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: s/o
• Nom complet: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
• Numéro d’acquisition GenBank: BC117443
• Symbole du gène: CD41
• Identification du gène (NCBI): 3674
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen. The HIP8 clone antibody specifically binds to the alpha chain of CD41.

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