Anticorps Recombinant de lapin anti-CD44

CD44 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241648F8

N° de cat : 98208-1-PBS

Synonymes

241648F8, CD44 antigen, ECMR-III, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor

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Galerie de données de validation

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  FC experiment of rat splenocytes using 98208-1-RR (same clone as 98208-1-PBS)

  1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat CD44 Rabbit Recombinant Antibody (98208-1-RR, Clone: 241648F8) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98208-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98208-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98208-1-RR against Rat CD44 were performed. The affinity constant is 1.02 nM.

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Informations sur le produit

98208-1-PBS cible CD44 dans les applications de FC et montre une réactivité avec des échantillons rat

• Réactivité: rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD44 Protéine recombinante Eg1458
• Nom complet: Cd44 molecule
• Masse moléculaire calculée: 40 kDa
• Numéro d’acquisition GenBank: XM_006234631.3
• Symbole du gène: Cd44
• Identification du gène (NCBI): 25406
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD44 is a type I transmembrane glycoprotein expressed on embryonic stem cells and in various levels on other cell types including connective tissues and bone marrow. CD44 expression is also upregulated in subpopulations of cancer cells and is recognized as a molecular marker for cancer stem cells (PMID: 29747682). It is a cell-surface receptor that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands (PMID: 10694938). Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.

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