Anticorps Recombinant de lapin anti-CD46

CD46 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

PerCP Fluorescent Dye

CloneNo.

241764C9

N° de cat : CP-98240

Synonymes

MCP, Membrane cofactor protein, MIC10, TLX, TRA2.10

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Galerie de données de validation

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  FC experiment of human PBMCs using CP-98240

  1x10^6 human PBMCs were surface stained with CoraLite® Plus 647 Anti-Human CD19, and 5 ul PerCP Anti-Human CD46 Rabbit RecAb (CP-98240, Clone: 241764C9) or unstained. Cells were not fixed.

• 

  FC experiment of human PBMCs using CP-98240

  1x10^6 human PBMCs were surface stained with 5 ul PerCP Anti-Human CD46 Rabbit RecAb (CP-98240, Clone: 241764C9) (red) or unstained (blue). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

CP-98240 cible CD46 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD46 Protéine recombinante Eg1770
• Nom complet: CD46 molecule, complement regulatory protein
• Masse moléculaire calculée: 42kDa
• Numéro d’acquisition GenBank: NM_172351.3
• Symbole du gène: CD46
• Identification du gène (NCBI): 4179
• Conjugaison: PerCP Fluorescent Dye
• Excitation/Emission maxima wavelengths: 482 nm / 677 nm
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD46, also known as Membrane cofactor protein (MCP) or MIC10, is a ubiquitously expressed type type-I transmembrane glycoprotein that acts as a cofactor for complement factor I to mediate inactivation of C3b and C4b deposited on host cells. CD46 is a receptor for a large number of pathogens, including measles virus and adenovirus (PMID: 20941397). CD46 plays a role in linking innate and adaptive immune responses. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations of the CD46 gene have been associated with some diseases including hemolytic uremic syndrome (PMID: 26054645). CD46 is expressed on most cells as four isoforms that are derived via alternative splicing (PMID: 15324743).

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