Anticorps Recombinant de lapin anti-CD49b

CD49b Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

AK7

N° de cat : 65583-1-MR

Synonymes

ITGA2, AK7, BR, Collagen receptor, GPIa

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Galerie de données de validation

• 

  FC experiment of human peripheral blood platelets using 65583-1-MR

  1x10^6 human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD49b (AK7) Mouse IgG2a RecAb (65583-1-MR, Clone: AK7) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: plaquettes de sang périphérique humain,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65583-1-MR cible CD49b dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Plaquettes humaines
• Nom complet: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
• Masse moléculaire calculée: 126 kDa
• Numéro d’acquisition GenBank: NM_002203
• Symbole du gène: Integrin alpha 2
• Identification du gène (NCBI): 3673
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

CD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets.

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