Anticorps Recombinant de lapin anti-CD49b

CD49b Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

AK7

N° de cat : 65583-1-PBS

Synonymes

ITGA2, AK7, BR, Collagen receptor, GPIa

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Galerie de données de validation

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  FC experiment of human peripheral blood platelets using 65583-1-MR (same clone as 65583-1-PBS)

  1x10^6 human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD49b (AK7) Mouse IgG2a RecAb (65583-1-MR, Clone: AK7) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. This data was developed using the same antibody clone with 65583-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65583-1-PBS cible CD49b dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Plaquettes humaines
• Nom complet: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
• Masse moléculaire calculée: 126 kDa
• Numéro d’acquisition GenBank: NM_002203
• Symbole du gène: Integrin alpha 2
• Identification du gène (NCBI): 3673
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets.

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