Anticorps Recombinant de lapin anti-CD6

CD6 Recombinant Antibody for Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test

Conjugaison

Non conjugué

CloneNo.

241965G6

N° de cat : 84508-1-PBS

Synonymes

CD6 molecule, Soluble CD6, T12, T-cell differentiation antigen CD6, TP120

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Galerie de données de validation

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  Sandwich ELISA standard curve of MP01358-2

  Sandwich ELISA standard curve of MP01358-2, Human CD6 Recombinant Matched Antibody Pair - PBS only. 84508-1-PBS was coated to a plate as the capture antibody and incubated with serial dilutions of standard Eg2079. 84508-2-PBS was HRP conjugated as the detection antibody. Range: 78.1-5000 pg/mL.

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  Sample test of MP01358-2

  The mean CD6 concentration was determined to be 20.8 ng/mL in MOLT-4 cell extract based on a 1.2 mg/mL extract load and 10.9 ng/mL in Jurkat cell extract based on a 4.2 mg/mL extract load.

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  Sample test of MP01358-2

  Serum of six individual healthy human donors was measured. The CD6 concentration of detected samples was determined to be 2,345.6 pg/mL with a range of 1,106.3-6,008.2 pg/mL.

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  Cytometric bead array standard curve of MP01358-2

  Cytometric bead array standard curve of MP01358-2, CD6 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84508-1-PBS. Detection antibody: 84508-2-PBS. Standard: Eg2079. Range: 0.781-100 ng/mL.

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  Affinity and Kinetic Characterization of 84508-1-PBS

  Biolayer interferometry (BLl) kinetic assays of 84508-1-PBS against Human CD6 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

84508-1-PBS cible CD6 dans les applications de Cytometric bead array, Sandwich ELISA, Indirect ELISA, Sample test et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD6 Protéine recombinante Eg2079
• Nom complet: CD6 molecule
• Numéro d’acquisition GenBank: BC033755
• Symbole du gène: CD6
• Identification du gène (NCBI): 923
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD6 is a type I transmembrane glycoprotein of 105-130 kDa that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harbouring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.

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