Anticorps Recombinant de lapin anti-CD6

CD6 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241471F3

N° de cat : 98161-1-PBS

Synonymes

241471F3, T-cell differentiation antigen CD6

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Galerie de données de validation

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  FC experiment of BALB/c mouse splenocytes using 98161-1-RR (same clone as 98161-1-PBS)

  1x10^6 BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD6 Rabbit Recombinant Antibody (98161-1-RR, Clone:241471F3) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD3. Cells were not fixed. This data was developed using the same antibody clone with 98161-1-PBS in a different storage buffer formulation.

• 

  FC experiment of BALB/c mouse splenocytes using 98161-1-RR (same clone as 98161-1-PBS)

  1x10^6 BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD6 Rabbit Recombinant Antibody (98161-1-RR, Clone:241471F3) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98161-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98161-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98161-1-RR against Mouse CD6 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

98161-1-PBS cible CD6 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD6 Protéine recombinante Eg1401
• Nom complet: CD6 antigen
• Masse moléculaire calculée: 72kDa
• Numéro d’acquisition GenBank: NM_009852.3
• Symbole du gène: Cd6
• Identification du gène (NCBI): 12511
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD6 is a type I transmembrane glycoprotein that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harboring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.

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