Anticorps Recombinant de lapin anti-CD6

CD6 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241471F3

N° de cat : 98161-1-RR

Synonymes

241471F3, T-cell differentiation antigen CD6

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Galerie de données de validation

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  FC experiment of BALB/c mouse splenocytes using 98161-1-RR

  1x10^6 BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD6 Rabbit Recombinant Antibody (98161-1-RR, Clone:241471F3) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD3. Cells were not fixed.

• 

  FC experiment of BALB/c mouse splenocytes using 98161-1-RR

  1x10^6 BALB/c mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD6 Rabbit Recombinant Antibody (98161-1-RR, Clone:241471F3) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98161-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98161-1-RR against Mouse CD6 were performed. The affinity constant is below 1 pM.

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Applications testées

• Résultats positifs en cytométrie: splénocytes de souris

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98161-1-RR cible CD6 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD6 Protéine recombinante Eg1401
• Nom complet: CD6 antigen
• Masse moléculaire calculée: 72kDa
• Numéro d’acquisition GenBank: NM_009852.3
• Symbole du gène: Cd6
• Identification du gène (NCBI): 12511
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

CD6 is a type I transmembrane glycoprotein that belongs to the scavenger receptor cysteine-rich superfamily (PMID: 21880988). It is composed of an extracellular region, which consists of three tandem SRCR domains, a transmembrane region, and a cytoplasmic tail devoid of intrinsic catalytic activity but harboring several phosphorylatable residues suitable for intracellular signal transduction (PMID: 38139340; 23711376). CD6 is expressed by T cells, medullary thymocytes, a subset of B cells and NK cells, and in some cells of the brain (PMID: 1919444; 21178331). CD6 plays a role in lymphocyte activation, proliferation, and survival processes via interaction with its endogenous ligands.

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