Anticorps Recombinant de lapin anti-CD63

CD63 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241964E1

N° de cat : 98318-1-PBS

Synonymes

Lysosome integral membrane protein 1, Lysosomal-associated membrane protein 3, Limp1, CD63 antigen, CD 63

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Galerie de données de validation

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  FC experiment of human peripheral blood platelets using 98318-1-RR (same clone as 98318-1-PBS)

  1x10^6 Thrombin-treated human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD63 Rabbit RecAb (98318-1-RR, Clone: 241964E1) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Untreated human peripheral blood platelets were surface stained with 0.25 ug Anti-Human CD63 Rabbit RecAb (98318-1-RR, Clone: 241964E1) and PE-conjugated Goat Anti-Rabbit IgG (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98318-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98318-1-PBS cible CD63 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: CD63 molecule
• Masse moléculaire calculée: 26 kDa
• Numéro d’acquisition GenBank: BC002349
• Symbole du gène: CD63
• Identification du gène (NCBI): 967
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD63 is a 30-60 kDa lysosomal membrane protein that belongs to the tetraspanin family. This protein plays many important roles in immuno-physiological functions. It mediates signal transduction events that regulate cell development, activation, growth, and motility. CD63 is expressed on activated platelets, thus it may function as a blood platelet activation marker. CD63 is a lysosomal membrane glycoprotein translocated to the plasma membrane after platelet activation. The CD63 tetraspanin is highly expressed in the early stages of melanoma and decreases in advanced lesions, suggesting it is a possible suppressor of tumor progression. Deficiency of this protein is associated with Hermansky-Pudlak syndrome.

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