Anticorps Monoclonal anti-CD7

CD7 Monoclonal Antibody for FC

Hôte / Isotype

Mouse / IgG2a, kappa

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

4H9

N° de cat : 65203-1-Ig

Synonymes

4H9, CD7 molecule, GP40, LEU-9, T cell antigen CD7

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Galerie de données de validation

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  FC experiment of human PBMCs using 65203-1-Ig

  1X10^6 human PBMCs were surface stained with 0.2 ug Anti-Human CD7 (65203-1-Ig, Clone:4H9) or Mouse IgG2a Isotype Control, and CoraLite®594-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:500, then CL405 Anti-Human CD4. Cells were not fixed. Lymphocytes were gated.

• 

  FC experiment of human PBMCs using 65203-1-Ig

  1X10^6 human PBMCs were surface stained with 0.2 ug Anti-Human CD7 (65203-1-Ig, Clone:4H9) or Mouse IgG2a Isotype Control, and CoraLite®594-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:500. Cells were not fixed. Lymphocytes were gated.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

65203-1-Ig cible CD7 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Cellules de leucémie lymphoblastique aiguë T
• Nom complet: CD7 molecule
• Masse moléculaire calculée: 240 aa, 25 kDa
• Numéro d’acquisition GenBank: BC009293
• Symbole du gène: CD7
• Identification du gène (NCBI): 924
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

CD7, also known as Leu-9 or GP40, is a 40-kDa single-pass type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD7 is expressed on thymocytes, T cells, NK cells, and cells in the early stages of T, B, and myeloid cell differentiation (PMID: 10530432). It is one of the earliest antigens to appear on cells of the T-lymphocyte lineage (PMID: 3501369). CD7 plays a significant role in T-cell and T-cell/B-cell interactions during early lymphoid development. It is involved in the regulation of cell signaling and biology, including T-cell activation, proliferation, and the expression of interleukin-2 receptor alpha (IL-2Rα) (PMID: 11485208). CD7 is not only a marker for T-cells but also has functional implications in immune cell interactions and adhesion. It can provide co-stimulatory signals and is associated with CD3 and CD45, participating in T-cell activation (PMID: 7523512).

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