Anticorps Recombinant de lapin anti-CD70

CD70 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241325D8

N° de cat : 98098-1-PBS

Synonymes

241325D8, CD27 L, CD27 ligand, CD27L, CD27-L

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Galerie de données de validation

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  FC experiment of U266 using 98098-1-RR (same clone as 98098-1-PBS)

  1x10^6 U266 cells were stained with 0.25 ug Anti-Human CD70 Rabbit Recombinant Antibody (98098-1-RR, Clone:241325D8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98098-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98098-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98098-1-RR against Human CD70 were performed. The affinity constant is 0.117 nM.

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Informations sur le produit

98098-1-PBS cible CD70 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: CD70 molecule
• Masse moléculaire calculée: 21 kDa
• Numéro d’acquisition GenBank: BC000725
• Symbole du gène: CD70
• Identification du gène (NCBI): 970
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis.

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