Anticorps Recombinant de lapin anti-CD70

CD70 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241553F2

N° de cat : 98212-1-PBS

Synonymes

241553F2, CD27 ligand, Cd27l, CD27-L, Cd27lg

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Galerie de données de validation

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  FC experiment of Mouse splenic leucocytes using 98212-1-RR (same clone as 98212-1-PBS)

  1x10^6 LPS treated Mouse splenic leucocytes were stained with 0.25 ug Anti-Mouse CD70 Rabbit Recombinant Antibody (98212-1-RR, Clone:241553F2) or 1x10^6 LPS untreated Mouse splenic leucocytes were stained with 0.25 ug Anti-Mouse CD70 Rabbit Recombinant Antibody (98212-1-RR, Clone:241553F2) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98212-1-PBS in a different storage buffer formulation.

• 

  FC experiment of Mouse splenic leucocytes using 98212-1-RR (same clone as 98212-1-PBS)

  1x10^6 LPS treated mouse splenic leukocytes were surface stained with 0.25 ug Anti-Mouse CD70 Rabbit Recombinant Antibody (98212-1-RR, Clone: 241553F2) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 LPS treated Mouse splenic leucocytes were surface stained with 0.25 ug Anti-Mouse CD70 Rabbit Recombinant Antibody (98212-1-RR, Clone: 241553F2) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98212-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98212-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98212-1-RR against Mouse CD70 were performed. The affinity constant is 37.8 pM.

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Informations sur le produit

98212-1-PBS cible CD70 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD70 Protéine recombinante Eg1294
• Nom complet: CD70 antigen
• Masse moléculaire calculée: 22 kDa
• Numéro d’acquisition GenBank: NM_011617.2
• Symbole du gène: Cd70
• Identification du gène (NCBI): 21948
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis. (PMID: 34991665; 26213107; 26098609)

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