Anticorps Recombinant de lapin anti-CD70

CD70 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

CoraLite® Plus 647 Fluorescent Dye

CloneNo.

241553F2

N° de cat : CL647-98212

Synonymes

241553F2

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Galerie de données de validation

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  FC experiment of mouse splenocytes using CL647-98212

  1x10^6 untreated or LPS-treated (3 days) mouse splenocytes were surface stained with 0.25 ug CoraLite® Plus 647 Anti-Mouse CD70 Rabbit RecAb (CL647-98212, Clone: 241553F2). Cells were not fixed.

• 

  FC experiment of mouse splenocytes using CL647-98212

  1x10^6 LPS-treated (3 days) mouse splenocytes were surface stained with 0.25 ug CoraLite® Plus 647 Anti-Mouse CD70 Rabbit RecAb (CL647-98212, Clone: 241553F2) (red) or 0.25 ug CoraLite® Plus 647 Rabbit IgG Isotype Control RecAb (CL647-98136, Clone: 240953C9) (blue). 1x10^6 untreated mouse splenocytes were surface stained with 0.25 ug CoraLite® Plus 647 Anti-Mouse CD70 Rabbit RecAb (CL647-98212, Clone: 241553F2) (black, dashed). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: LPS-treated mouse splenocytes

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

CL647-98212 cible CD70 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD70 Protéine recombinante Eg1294
• Nom complet: CD70 antigen
• Masse moléculaire calculée: 22 kDa
• Numéro d’acquisition GenBank: NM_011617.2
• Symbole du gène: Cd70
• Identification du gène (NCBI): 21948
• Conjugaison: CoraLite® Plus 647 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 654 nm / 674 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD70, also known as tumor necrosis factor ligand superfamily member 7 (TNFSF7) or CD27 ligand (CD27L), is a transmembrane protein that plays a significant role in the immune system. It is the unique ligand for CD27, a member of the tumor necrosis factor receptor (TNFR) family, and is transiently upregulated upon stimulation of immune cells. CD70 is expressed on lymphocytes and dendritic cells, and its expression can be regulated by activation signals received via toll-like receptors (TLRs), CD40, and the antigen receptor MHC II. It provides complex and not completely understood signaling for B cell development. CD70 is also expressed on various solid tumors and hematolymphoid malignancies, where it may contribute to a poor prognosis. (PMID: 34991665; 26213107; 26098609)

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