Anticorps Recombinant de lapin anti-CD70

CD70 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

PE Fluorescent Dye

CloneNo.

241325D8

N° de cat : PE-FcA98098

Synonymes

241325D8, CD27 L, CD27 ligand, CD27L, CD27-L

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Galerie de données de validation

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  FC experiment of U266 using PE-FcA98098

  1x10^6 U266 cells were surface stained with 5 ul PE Anti-Human CD70 Rabbit Recombinant Antibody (PE-FcA98098, Clone: 241325D8) (red), or 5 ul PE Rabbit IgG Isotype Control Recombinant Antibody (PE-FcA98136, Clone: 240953C9) (blue). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: U266 cells,

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

PE-FcA98098 cible CD70 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: CD70 molecule
• Masse moléculaire calculée: 21 kDa
• Numéro d’acquisition GenBank: BC000725
• Symbole du gène: CD70
• Identification du gène (NCBI): 970
• Conjugaison: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD70 is the membrane-bound ligand of the CD27 receptor, which belongs to the tumor necrosis factor receptor superfamily. CD70 is not expressed in non-lymphoid normal tissue but is overexpressed in tumor cells of various solid cancers, diffuse large B-cell and follicular lymphoma and the malignant cells of Hodgkin lymphoma, Waldenström macroglobulinemia, and multiple myeloma (PMID: 28651374, 20699361 ). CD70/CD27 interactions play an important role in providing co-stimulation during the development of functional lymphocytes; strict control of CD70 expression is required for optimal signaling for immune cell activation (PMID: 21304103).

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