Anticorps Monoclonal anti-CD71

CD71 Monoclonal Antibody for FC

Hôte / Isotype

Rat / IgG2a, kappa

Réactivité testée

souris et plus (1)

Applications

IF, FC

Conjugaison

Non conjugué

Publications(2)

CloneNo.

RI7217

N° de cat : 65289-1-Ig

Synonymes

Tfrc, RI7217, TFR, TFR1, TR

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Galerie de données de validation

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  FC experiment of C57BL/6 mouse bone marrow cells using 65289-1-Ig

  1X10^6 C57BL/6 mouse bone marrow cells were surface co-stained with APC Anti-Mouse TER-119 (TER-119) and 0.5 ug Anti-Mouse CD71 (65289-1-Ig, Clone: RI7217) or 0.5 ug Rat IgG2a Isotype Control (2A3), and FITC anti-Rat IgG2a Antibody at dilution 1:100. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: C57BL/6 mouse bone marrow cells,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• IF: See 1 publications below
• FC: See 1 publications below

Informations sur le produit

65289-1-Ig cible CD71 dans les applications de IF, FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Rat / IgG2a, kappa
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: DMSO induced Friend erythroleukemia 745.6
• Nom complet: transferrin receptor
• Numéro d’acquisition GenBank: BC054522
• Symbole du gène: CD71
• Identification du gène (NCBI): 22042
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

CD71, also known as transferrin receptor protein 1 (TfR1), is a transmembrane glycoprotein composed of two disulfide-linked monomers, each of 90 kDa molecular weight. Each monomer binds one holo-transferrin molecule, creating an iron-Tf-TfR complex that enters the cell by endocytosis. CD71 is present on actively proliferating cells and is essential for iron transport into proliferating cells.

Publications

Species	Application	Title
mouse	FC	Cell Chem Biol; Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor; Authors - Ling-Yan Su
human	IF	Cancer Discov; Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation; Authors - Alessio Ugolini

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