Anticorps Recombinant de lapin anti-CD72

CD72 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242846D10

N° de cat : 98354-3-PBS

Synonymes

B-cell differentiation antigen CD72, Ly32, Ly-32, Lyb-2, Lymphocyte antigen 32

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98354-3-RR (same clone as 98354-3-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD72 Rabbit RecAb (98354-3-RR, Clone: 242846D10) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with CoraLite® Plus 750 Anti-Mouse CD19. Cells were not fixed. This data was developed using the same antibody clone with 98354-3-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98354-3-RR (same clone as 98354-3-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CD72 Rabbit RecAb (98354-3-RR, Clone: 242846D10) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98354-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98354-3-PBS cible CD72 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: CD72 antigen
• Masse moléculaire calculée: 40 kDa
• Numéro d’acquisition GenBank: NM_007654.2
• Symbole du gène: Cd72
• Identification du gène (NCBI): 12517
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD72 is a type II transmembrane glycoprotein of 39-45 kDa and is expressed as a disulphide-linked homodimer (PMID: 1711157). CD72 is a pan B-cell marker covering the full range of differentiation from the very early stages of B cells to mature surface Ig+ B cells (PMID: 1384316). It is expressed in all stages of B cell development except plasma cells. CD72 is also expressed by dendritic cells, tissue macrophages in the red pulp of the spleen and von Kupffer cells in the liver (PMID: 8561576; 1384316). CD72 is the ligand for CD5 (PMID: 1711157). CD72 is a negative regulator of BCR signaling (PMID: 9590210). Interaction of CD100 with CD72 strictly tunes the strength of BCR signals and is essential for maintaining immunological homeostasis as well as generating a proper immune response (PMID: 16113236).

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