Anticorps Recombinant de lapin anti-CD74

CD74 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250520C1

N° de cat : 98478-2-PBS

Synonymes

Class-II-associated invariant chain peptide, DHLAG, HLADG, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain

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Galerie de données de validation

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  FC experiment of human PBMCs using 98478-2-RR (same clone as 98478-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD74 Rabbit RecAb (98478-2-RR, Clone: 250520C1) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD19. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98478-2-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98478-2-RR (same clone as 98478-2-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD74 Rabbit RecAb (98478-2-RR, Clone: 250520C1) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98478-2-PBS in a different storage buffer formulation.

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Informations sur le produit

98478-2-PBS cible CD74 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD74 Protéine recombinante Eg1945
• Nom complet: CD74 molecule, major histocompatibility complex, class II invariant chain
• Masse moléculaire calculée: 26 kDa
• Numéro d’acquisition GenBank: NM_001025159.3
• Symbole du gène: CD74
• Identification du gène (NCBI): 972
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD74, also known as MHC class II invariant chain Ii or HLA-DR-associated invariant chain, is a non-polymorphic type II transmembrane glycoprotein. CD74 is mainly distributed in B cells, monocytes, Langerhans cells, dendritic cells and thymic epithelial cells, and is also expressed in epithelial cells. CD74 plays a key role in MHC class II antigen processing and also serves as a cell surface receptor for the macrophage cytokine MIF. CD74 plays an important role in cardiovascular diseases such as atherosclerosis, ischemic heart disease, and myocardial hypertrophy.(PMID: 15475450; PMID: 27752708; PMID: 38992165; PMID: 36712241).

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