Anticorps Recombinant de lapin anti-CD80

CD80 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242913B11

N° de cat : 98384-1-PBS

Synonymes

Activation B7 1 antigen, Activation B7-1 antigen, B7, B7 1, B7-1

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Galerie de données de validation

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  FC experiment of Raji using 98384-1-RR (same clone as 98384-1-PBS)

  1x10^6 Raji (left) or HUVEC cells (right) were surface stained with 0.25 ug Anti-Human CD80 Rabbit RecAb (98384-1-RR, Clone: 242913B11) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98384-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98384-1-PBS cible CD80 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: CD80 molecule
• Masse moléculaire calculée: 33 kDa
• Numéro d’acquisition GenBank: NM_005191
• Symbole du gène: CD80
• Identification du gène (NCBI): 941
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)

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