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Anticorps Polyclonal de lapin anti-CD83

CD83 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27873-1-PBS

Synonymes

B cell activation protein, B-cell activation protein, BL11, CD83 antigen, CD83 molecule

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using CD83 Polyclonal antibody (27873-1-AP)

    WB analysis using 27873-1-AP (same clone as 27873-1-PBS)

    Untreated and PNGF treated Raji cells were subjected to SDS PAGE followed by western blot with 27873-1-AP (CD83 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27873-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CD83 Polyclonal antibody (27873-1-AP)

    WB analysis using 27873-1-AP (same clone as 27873-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27873-1-AP (CD83 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27873-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using CD83 Polyclonal antibody (27873-1-AP)

    IHC staining of human tonsillitis using 27873-1-AP (same clone as 27873-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 27873-1-AP (CD83 antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27873-1-PBS in a different storage buffer formulation.

Informations sur le produit

27873-1-PBS cible CD83 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène CD83 Protéine recombinante Ag27467
Nom complet CD83 molecule
Masse moléculaire calculée 205 aa, 23 kDa
Poids moléculaire observé 37-50kDa, 23kDa
Numéro d’acquisition GenBankBC030830
Symbole du gène CD83
Identification du gène (NCBI) 9308
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CD83 is a member of the immunoglobulin (Ig) superfamily, consisting of an extracellular V-type Ig-like domain, a transmembrane domain, and a cytoplasmic tail. CD83 is one of the most prominent markers for fully matured dendritic cells (DCs) (PMID: 17334966). It is also found on the surface of other activated hematopoietic cells, including lymphocytes, monocytes, macrophages, and neutrophils (PMID: 31231400; 17334966). CD83 regulates the maturation, activation, and homeostasis of numerous immune cells (PMID: 31231400; 32362900). CD83 can also expressed as a soluble form. Soluble CD83 can bind to DCs and inhibit their maturation (PMID: 17334966; 12403928). PNGase F (peptide N-glycosidase F) digestion reduced the 37 and 50 kDa CD83 forms to 28 kDa (PMID: 15320871).

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