Anticorps Recombinant de lapin anti-CD89

CD89 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241426H1

N° de cat : 84384-5-PBS

Synonymes

IgA Fc receptor, FCAR, 241426H1

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Galerie de données de validation

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  WB analysis using 84384-5-RR (same clone as 84384-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84384-5-RR (CD89 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84384-5-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84384-5-RR

  Biolayer interferometry (BLl) kinetic assays of 84384-5-RR against Human CD89 were performed. The affinity constant is 13.5 nM.

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Informations sur le produit

84384-5-PBS cible CD89 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: Fc fragment of IgA, receptor for
• Masse moléculaire calculée: 287 aa, 32 kDa
• Poids moléculaire observé: 65-70 kDa
• Numéro d’acquisition GenBank: BC027953
• Symbole du gène: CD89
• Identification du gène (NCBI): 2204
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FcαRI (CD89) is a member of the Fc receptor immunoglobulin superfamily, constitutively expressed on cells of the myeloid lineage like neutrophils, eosinophils, monocytes macrophages, and platelets (PMID: 28103138). CD89 expression and activation are increased in human blood phagocytes following bacterial infection, together with increased expression and association of FcRγ with CD89 (PMID: 34756952). CD89 binds both subclasses of IgA (IgA1 and IgA2) with moderate affinity, but also binds other molecules such as TfR1, C-reactive protein and bacterial ligands. CD89 represents an effective target molecule for immunotherapy mediated by bispecific antibodies (PMID: 37081893).

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