Anticorps Recombinant de lapin anti-CD98/SLC3A2

CD98/SLC3A2 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241755D6

N° de cat : 98190-1-PBS

Synonymes

CD98, SLC3A2, MDU1, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain

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Galerie de données de validation

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  FC experiment of human PBMCs using 98190-1-RR (same clone as 98190-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98190-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98190-1-RR (same clone as 98190-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD98 Rabbit Recombinant Antibody (98190-1-RR, Clone: 241755D6) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98190-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98190-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98190-1-RR against Human CD98/SLC3A2 were performed. The affinity constant is 5.97 nM.

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Informations sur le produit

98190-1-PBS cible CD98/SLC3A2 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
• Masse moléculaire calculée: 68 kDa
• Numéro d’acquisition GenBank: NM_002394.5
• Symbole du gène: CD98
• Identification du gène (NCBI): 6520
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD98 is a 125-kDa type II membrane glycoprotein heterodimer composed of a 40-kDa non-glycosylated light chain (amino-acid transporter, encoded by the SLC7A5) and an 85-kDa glycosylated heavy chain (CD98hc, encoded by the SLC3A2) (PMID: 11507094). CD98hc also interacts with certain integrin b-subunits to regulate cell migration, survival, proliferation, and adhesion/polarity. CD98hc is overexpressed on the cell surface of many cancers and increased CD98hc expression is associated with the development and progression of tumors.(PMID:25084765). Molecular orientation studies have demonstrated that the C-terminal tail of human CD98 (hCD98), which contains a PDZ-binding domain, is extracellular (PMID: 18625289).

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