Anticorps Monoclonal anti-CDC6
CDC6 Monoclonal Antibody for
Hôte / Isotype
Mouse / IgG1
Réactivité testée
Humain, rat, souris
Applications
Conjugaison
CoraLite®555 Fluorescent Dye
CloneNo.
6F12D2
N° de cat : CL555-66021
Synonymes
Galerie de données de validation
Informations sur le produit
CL555-66021 cible CDC6 dans les applications de et montre une réactivité avec des échantillons Humain, rat, souris
| Réactivité | Humain, rat, souris |
| Hôte / Isotype | Mouse / IgG1 |
| Clonalité | Monoclonal |
| Type | Anticorps |
| Immunogène | CDC6 Protéine recombinante Ag17958 |
| Nom complet | cell division cycle 6 homolog (S. cerevisiae) |
| Masse moléculaire calculée | 560 aa, 63 kDa |
| Poids moléculaire observé | 65 kDa |
| Numéro d’acquisition GenBank | BC025232 |
| Symbole du gène | CDC6 |
| Identification du gène (NCBI) | 990 |
| Conjugaison | CoraLite®555 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 557 nm / 570 nm |
| Forme | Liquide |
| Méthode de purification | Purification par protéine G |
| Tampon de stockage | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Conditions de stockage | Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
CDC6, also named as CDC18L and HsCDC18, belongs to the CDC6/cdc18 family. It is involved in the initiation of DNA replication and functions as a regulator at the early steps of DNA replication. It also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5). MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human CDC6.
