Anticorps Polyclonal de lapin anti-CDY1B

CDY1B Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33231-1-PBS

Synonymes

CDY1, CDY1A, EC:2.3.1.48, Testis-specific chromodomain protein Y 1

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Galerie de données de validation

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  WB analysis using 33231-1-AP (same clone as 33231-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33231-1-AP (CDY1B antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33231-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33231-1-PBS cible CDY1B dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CDY1B Protéine recombinante Ag37962
• Nom complet: chromodomain protein, Y-linked, 1B
• Masse moléculaire calculée: 540 aa, 60 kDa/554 aa, 62 kDa
• Poids moléculaire observé: 65 kDa
• Numéro d’acquisition GenBank: BC132929
• Symbole du gène: CDY1B
• Identification du gène (NCBI): 253175
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The CDY1B gene, also known as Chromodomain Y-Linked 1B, is a Protein Coding gene located on the Y chromosome. It is one of the two identical copies of the CDY1 gene within the AZFc region of the human Y chromosome. As a histone acetyltransferase, CDY1B exhibits a strong preference for histone 4, suggesting its involvement in both spermatogenic histone replacement and DNA transcription. It plays a significant role in the chromatin remodeling of round spermatid nuclei, contributing to the transition from histone-based chromatin to protamine-based chromatin during spermatogenesis. This transition is essential for the condensation of sperm DNA and the formation of mature sperm. Deletion of either CDY1 can lead to spermatogenic failure and male infertility.

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