Anticorps Recombinant de lapin anti-CEACAM1/3/6 (CD66a/c/d)

CEACAM1/3/6 (CD66a/c/d) Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240497E12

N° de cat : 98061-1-RR

Synonymes

CD66a/c/d, CD66c, CEACAM3, CEACAM6, CEACAM1

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Galerie de données de validation

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  FC experiment of human peripheral blood leukocytes using 98061-1-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM1/3/6 (CD66a/c/d) Rabbit Recombinant Antibody (98061-1-RR, Clone:240497E12) or Isotype Control and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with APC Anti-Human CD16. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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  FC experiment of human peripheral blood leukocytes using 98061-1-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM1/3/6 (CD66a/c/d) Rabbit Recombinant Antibody (98061-1-RR, Clone:240497E12) (red) or Isotype Control (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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  Affinity and Kinetic Characterization of 98061-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98061-1-RR against Human CEACAM1/CD66a were performed. The affinity constant is 4.34 nM.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98061-1-RR cible CEACAM1/3/6 (CD66a/c/d) dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
• Masse moléculaire calculée: 526 aa, 58 kDa
• Numéro d’acquisition GenBank: BC014473
• Symbole du gène: CEACAM1
• Identification du gène (NCBI): 634
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

CEACAM1, also known as CD66a or BGP (biliary glycoprotein), is a member of the cacinoembryonic antigen (CEA) family which belongs to the immunoglobulin superfamily of cell adhesion molecules (PMID: 16919437). CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in the control of cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM1 is a transmembrane glycoprotein that is expressed on epithelial, endothelial, and immune cells (PMID: 30314283). CEACAM1 has been demonstrated to play a role in morphogenesis, apoptosis, angiogenesis, cell proliferation, cell motility, fibrosis, and immunity (PMID: 31604530). This antibody is raised against 35-428 aa of human CEACAM1/CD66a and can cross-react with CEACAM6/CD66c and CEACAM3/CD66d.

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