Anticorps Recombinant de lapin anti-CEACAM3/6 (CD66c/d)

CEACAM3/6 (CD66c/d) Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241254D1

N° de cat : 98169-1-RR

Synonymes

CD66c, CEACAM3/CD66d, CEACAM6, CEACAM6/CD66c, CEACAM3

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Galerie de données de validation

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  FC experiment of human peripheral blood leukocytes using 98169-1-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM3/6 (CD66c/d) Rabbit Recombinant Antibody (98169-1-RR, Clone: 241254D1) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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  Affinity and Kinetic Characterization of 98169-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98169-1-RR against Human CEACAM3/6 (CD66c/d) were performed. The affinity constant is 2.19 nM.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes, FC receptor blocked human peripheral blood leukocytes

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98169-1-RR cible CEACAM3/6 (CD66c/d) dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: carcinoembryonic antigen-related cell adhesion molecule 3
• Masse moléculaire calculée: 252 aa, 27 kDa
• Numéro d’acquisition GenBank: BC106728
• Symbole du gène: CEACAM3
• Identification du gène (NCBI): 1084
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM3, also named as CD66d and CGM1, is exclusively expressed on granulocytes and acts as the major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms (PMID: 18606569). CEACAM6, also known as CD66c, is normally expressed on the surface of myeloid and epithelial surfaces and upregulated preferentially at the apical/luminal membranes of many tumors (PMID: 27595061; 35082925). This antibody is raised against 35-155 aa of human CEACAM3/CD66d and can cross-react with CEACAM6/CD66c.

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