Anticorps Recombinant de lapin anti-CEACAM3/6 (CD66c/d)

CEACAM3/6 (CD66c/d) Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

APC Fluorescent Dye

CloneNo.

241254D1

N° de cat : APC-FcA98169

Synonymes

CEACAM3, Carcinoembryonic antigen CGM1, Carcinoembryonic antigen-related cell adhesion molecule 3, CD66D, CGM1

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Galerie de données de validation

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  FC experiment of human peripheral blood leukocyte using APC-FcA98169

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul APC Anti-Human CEACAM3/6 (CD66c/d) Rabbit RecAb (APC-FcA98169, Clone: 241254D1) or APC Rabbit IgG Isotype Control RecAb (APC-FcA98136, Clone: 240953C9). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

APC-FcA98169 cible CEACAM3/6 (CD66c/d) dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CEACAM3/6 (CD66c/d) Protéine recombinante Eg0144
• Nom complet: carcinoembryonic antigen-related cell adhesion molecule 3
• Masse moléculaire calculée: 252 aa, 27 kDa
• Numéro d’acquisition GenBank: BC106728
• Symbole du gène: CEACAM3
• Identification du gène (NCBI): 1084
• Conjugaison: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM3, also named as CD66d and CGM1, is exclusively expressed on granulocytes and acts as the major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms (PMID: 18606569). CEACAM6, also known as CD66c, is normally expressed on the surface of myeloid and epithelial surfaces and upregulated preferentially at the apical/luminal membranes of many tumors (PMID: 27595061; 35082925). This antibody is raised against 35-155 aa of human CEACAM3/CD66d and can cross-react with CEACAM6/CD66c.

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