Anticorps Recombinant de lapin anti-CEACAM5/8 (CD66b/e)

CEACAM5/8 (CD66b/e) Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

230353B7

N° de cat : 98012-1-RR

Synonymes

CD66e, CEACAM5, CEACAM5/CD66e, CEACAM8/CD66b, CD66b

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Galerie de données de validation

• 

  FC experiment of human peripheral blood leukocytes using 98012-1-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM5/8 (CD66b/e) Rabbit Recombinant Antibody (98012-1-RR, Clone:230353B7) or 0.25 ug Isotype Control, and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98012-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98012-1-RR against Human CEACAM5/8 (CD66b/e) were performed. The affinity constant is 2.31 nM.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98012-1-RR cible CEACAM5/8 (CD66b/e) dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CEACAM5/8 (CD66b/e) Protéine recombinante Eg32133
• Nom complet: CEACAM5/8 (CD66b/e)
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). Carcinoembryonic antigen (CEA), also known as CEACAM5 or CD66e mainly serves as a cell adhesion molecule mediating intercellular contact by both homophilic and heterophilic binding (PMID: 21731662). CEACAM8, also known as CD66b, CGM6 or NCA-95, is a glycosylphosphatidylinositol (GPI)-linked glycoprotein expressed on granulocytes and is involved in regulating adhesion and activation of eosinophils (PMID: 8104998; 18056392; 18056392). This antibody is raised against 35-319 aa of human CEACAM8/CD66b and can cross-react with CEACAM5/CD66e.

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