Anticorps Monoclonal anti-Properdin/PFC

Properdin/PFC Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, porc, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1D5A9

N° de cat : 66788-1-PBS

Synonymes

CFP, 1D5A9, BFD, Complement factor P, complement factor properdin

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Galerie de données de validation

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  WB analysis of Jurkat using 66788-1-Ig (same clone as 66788-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 66788-1-Ig (CFP antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66788-1-PBS in a different storage buffer formulation.

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  WB analysis of human plasma using 66788-1-Ig (same clone as 66788-1-PBS)

  human plasma were subjected to SDS PAGE followed by western blot with 66788-1-Ig (CFP antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66788-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66788-1-PBS cible Properdin/PFC dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat

• Réactivité: Humain, porc, rat
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Properdin/PFC Protéine recombinante Ag9798
• Nom complet: complement factor properdin
• Masse moléculaire calculée: 469 aa, 51 kDa
• Poids moléculaire observé: 50 kDa, 100 kDa, 150 kDa
• Numéro d’acquisition GenBank: BC015756
• Symbole du gène: CFP
• Identification du gène (NCBI): 5199
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CFP, also named as Properdin or PFC, is a 469 amino acid protein, which contains 7 TSP type-1 domains. CFP as secreted protein is a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin deficiency poses a significant risk for severe meningococcal infections (PMID: 22229731). Properdin may be novel biomarker for future risk of type 2 diabetes (PMID: 22338105). In plasma, properdin exists as dimers, trimers or tetramers.

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