Anticorps Recombinant de lapin anti-CFP

CFP Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250654E3

N° de cat : 85999-1-PBS

Synonymes

BFD, Complement factor P, complement factor properdin, PFC

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Galerie de données de validation

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  WB analysis of human plasma using 85999-1-RR (same clone as 85999-1-PBS)

  human plasma were subjected to SDS PAGE followed by western blot with 85999-1-RR (CFP antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85999-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 85999-1-RR (same clone as 85999-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85999-1-RR (CFP antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85999-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 85999-1-RR

  Biolayer interferometry (BLl) kinetic assays of 85999-1-RR against Human CFP were performed. The affinity constant is 0.98 nM.

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Informations sur le produit

85999-1-PBS cible CFP dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CFP Protéine recombinante Eg2219
• Nom complet: complement factor properdin
• Masse moléculaire calculée: 469 aa, 51 kDa
• Poids moléculaire observé: 55 kDa
• Numéro d’acquisition GenBank: BC015756
• Symbole du gène: CFP
• Identification du gène (NCBI): 5199
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CFP, also named as Properdin or PFC, is a 469 amino acid protein, which contains 7 TSP type-1 domains. CFP as secreted protein is a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin deficiency poses a significant risk for severe meningococcal infections (PMID: 22229731). Properdin may be novel biomarker for future risk of type 2 diabetes (PMID: 22338105).

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