Anticorps Polyclonal de lapin anti-CHD1L

CHD1L Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32923-1-PBS

Synonymes

ALC1, Amplified in liver cancer protein 1, Chromodomain-helicase-DNA-binding protein 1-like, EC:3.6.4.-

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Galerie de données de validation

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  WB analysis using 32923-1-AP (same clone as 32923-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32923-1-AP (CHD1L antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32923-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32923-1-PBS cible CHD1L dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CHD1L Protéine recombinante Ag38526
• Nom complet: chromodomain helicase DNA binding protein 1-like
• Masse moléculaire calculée: 101kDa，897aa
• Poids moléculaire observé: 101 kDa
• Numéro d’acquisition GenBank: NM_004284.5
• Symbole du gène: CHD1L
• Identification du gène (NCBI): 9557
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like), also known as ALC1 (Amplified in Liver Cancer 1), encodes a multifunctional protein involved in various cellular processes such as chromatin remodeling, cell differentiation, and development. CHD1L acts as an ATP-dependent chromatin remodeling enzyme with an ATPase catalytic domain activated by double-stranded DNA. It interacts with PARP1 (poly-ADP-ribose polymerase 1) to promote chromatin relaxation at DNA damage sites, facilitating DNA repair. Overexpression of CHD1L leads to dysregulation of downstream targets in various cancers.

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