Anticorps Polyclonal de lapin anti-CHRNG

CHRNG Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 21928-1-PBS

Synonymes

ACHRG, Acetylcholine receptor subunit gamma

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Galerie de données de validation

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  WB analysis using 21928-1-AP (same clone as 21928-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21928-1-AP (CHRNG antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21928-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 21928-1-AP (same clone as 21928-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21928-1-AP (CHRNG antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21928-1-PBS in a different storage buffer formulation.

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Informations sur le produit

21928-1-PBS cible CHRNG dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CHRNG Protéine recombinante Ag16505
• Nom complet: cholinergic receptor, nicotinic, gamma
• Masse moléculaire calculée: 465 aa, 52 kDa
• Poids moléculaire observé: 58 kDa
• Numéro d’acquisition GenBank: BC111802
• Symbole du gène: CHRNG
• Identification du gène (NCBI): 1146
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Acetylcholine receptor subunit gamma is a protein that in humans is encoded by the CHRNG gene. The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.

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