Anticorps Polyclonal de lapin anti-CIITA

CIITA Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications(1)

N° de cat : 55099-1-AP

Synonymes

C2TA, CIITA, CIITAIV, MHC class II transactivator, MHC2TA, NLRA

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Galerie de données de validation

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  WB analysis of K-562 using 55099-1-AP

  K-562 cells were subjected to SDS PAGE followed by western blot with 55099-1-AP (CIITA antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules K-562

Dilution recommandée

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below

Informations sur le produit

55099-1-AP cible CIITA dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: class II, major histocompatibility complex, transactivator
• Masse moléculaire calculée: 124 kDa
• Poids moléculaire observé: 120-130 kDa
• Numéro d’acquisition GenBank: NM_000246
• Symbole du gène: CIITA
• Identification du gène (NCBI): 4261
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20 ℃. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CIITA, also naned as MHC2TA, is a 1130 amino acid protein, which Interacts with ZXDA and ZXDC. MHC class II molecules are heterodimeric cell surface glycoproteins expressed on B cells, macrophages and dendritic cells, which present antigens to CD4+ T cells. CIITA (class II transactivator) acts as a coactivator for MHC class II-specific gene expression and negatively regulates the IL-4 gene promoter during T cell differentiation. IFNg induces CIITA gene expression via JAK1 and Stat1 pathways. T Defects of CIITA and RFX-B have been implicated as causes of Bare Lymphocyte Syndrome (BLS), which is characterized by the absence of MHC class II transcription and severe immunodeficiencies.

Publications

Species	Application	Title
human	WB	Front Oncol; Identification and validation of m6A-GPI signatures as a novel prognostic model for colorectal cancer; Authors - Bin Ma

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