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Anticorps Polyclonal de lapin anti-CIITA

CIITA Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 55099-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of K-562 cells using CIITA Polyclonal antibody (55099-1-AP)

    WB analysis of K-562 using 55099-1-AP (same clone as 55099-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 55099-1-AP (CIITA antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55099-1-PBS in a different storage buffer formulation.

Informations sur le produit

55099-1-PBS cible CIITA dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet class II, major histocompatibility complex, transactivator
Masse moléculaire calculée 124 kDa
Poids moléculaire observé 120-130 kDa
Numéro d’acquisition GenBankNM_000246
Symbole du gène CIITA
Identification du gène (NCBI) 4261
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CIITA, also naned as MHC2TA, is a 1130 amino acid protein, which Interacts with ZXDA and ZXDC. MHC class II molecules are heterodimeric cell surface glycoproteins expressed on B cells, macrophages and dendritic cells, which present antigens to CD4+ T cells. CIITA (class II transactivator) acts as a coactivator for MHC class II-specific gene expression and negatively regulates the IL-4 gene promoter during T cell differentiation. IFNg induces CIITA gene expression via JAK1 and Stat1 pathways. T Defects of CIITA and RFX-B have been implicated as causes of Bare Lymphocyte Syndrome (BLS), which is characterized by the absence of MHC class II transcription and severe immunodeficiencies.

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