Anticorps Monoclonal anti-CLCC1

CLCC1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

3C4B4

N° de cat : 68853-7-PBS

Synonymes

Mid-1-related chloride channel protein 1, MCLC, KIAA0761, Chloride channel CLIC-like protein 1, chloride channel CLIC like 1

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Galerie de données de validation

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  WB analysis of hTERT-RPE1 using 68853-7-Ig (same clone as 68853-7-PBS)

  hTERT-RPE1 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

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  WB analysis of COLO 320 using 68853-7-Ig (same clone as 68853-7-PBS)

  COLO 320 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

• 

  WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

• 

  WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

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Informations sur le produit

68853-7-PBS cible CLCC1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CLCC1 Protéine recombinante Ag24682
• Nom complet: chloride channel CLIC-like 1
• Masse moléculaire calculée: 551 aa, 62 kDa
• Poids moléculaire observé: 50-60 kDa
• Numéro d’acquisition GenBank: BC002939
• Symbole du gène: CLCC1
• Identification du gène (NCBI): 23155
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).

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