Anticorps Polyclonal de lapin anti-CLCN7

CLCN7 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29230-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 29230-1-AP (same clone as 29230-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29230-1-AP (CLCN7 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29230-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29230-1-PBS cible CLCN7 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CLCN7 Protéine recombinante Ag29882
• Nom complet: chloride channel 7
• Masse moléculaire calculée: 805 aa, 89 kDa
• Poids moléculaire observé: 70 kDa
• Numéro d’acquisition GenBank: BC012737
• Symbole du gène: CLCN7
• Identification du gène (NCBI): 1186
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The intracellular CLC chloride channel family members ClC-3, ClC-4, and ClC-5 have been proposed as the primary endosomal chloride conductance providers. ClC-7 is expressed in late endosomes and lysosomes, but there is disagreement in the literature regarding its contribution to acidification. More recently, the cystic fibrosis (CF) transmembrane conductance regulator chloride channel (CFTR) was proposed as the specific counter-ion conductance necessary for lysosomal acidification in alveolar macrophages. (PMID: 20566682)

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