Anticorps Recombinant de lapin anti-CLEC10A/CD301

CLEC10A/CD301 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241857C11

N° de cat : 98245-1-PBS

Synonymes

CLEC10A, C-type lectin domain family 10 member A, CLECSF14, CLECSF13, CD301

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Galerie de données de validation

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  FC experiment of Human immature monocyte-derived dendritic cells using 98245-1-RR (same clone as 98245-1-PBS)

  1x10^6 Human immature monocyte-derived dendritic cells were surface stained with 0.25 ug Anti-Human CLEC10A/CD301 Rabbit Recombinant Antibody (98245-1-RR, Clone: 241857C11) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98245-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98245-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98245-1-RR against Human CLEC10A/CD301 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

98245-1-PBS cible CLEC10A/CD301 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: C-type lectin domain family 10, member A
• Masse moléculaire calculée: 316 aa, 35 kDa
• Numéro d’acquisition GenBank: BC039011
• Symbole du gène: CLEC10A
• Identification du gène (NCBI): 10462
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

C-type lectin domain family 10 member A (CLEC10A), also known as CD301, macrophage galactose-type C-type lectin (MGL), DC-asialoglyco protein receptor (DC-ASGP-R) or human macrophage lectin (HML), is a type II transmembrane glycoprotein having a calcium-dependent carbohydrate recognition domain (PMID: 8598452; 11919201; 11698450). CLEC10A is expressed exclusively by myeloid professional antigen-presenting cells such as immature dendritic cells (DCs) and alternatively activated macrophages (PMID: 16998493). CLEC10A is a marker for human CD1c+ DCs (cDC2) (PMID: 29755453). It functions as an endocytic receptor for glycosylated antigens (PMID: 11919201).

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