Anticorps Polyclonal de lapin anti-CLEC5A

CLEC5A Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18248-1-PBS

Synonymes

MDL-1, MDL1, MDL 1, C-type lectin superfamily member 5, C-type lectin domain family 5 member A

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Galerie de données de validation

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  WB analysis using 18248-1-AP (same clone as 18248-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18248-1-AP (CLEC5A antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18248-1-PBS in a different storage buffer formulation.

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Informations sur le produit

18248-1-PBS cible CLEC5A dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CLEC5A Protéine recombinante Ag13025
• Nom complet: C-type lectin domain family 5, member A
• Masse moléculaire calculée: 188 aa, 22 kDa
• Poids moléculaire observé: 36 kDa
• Numéro d’acquisition GenBank: BC112099
• Symbole du gène: CLEC5A
• Identification du gène (NCBI): 23601
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

C-type lectin domain family 5 member A (CLEC5A, also known as CLECSF5 and MDL1) is a spleen tyrosine kinase (Syk)-coupled receptor abundantly expressed by monocytes, macrophages and neutrophils (PMID: 10449773). It has a pivotal function in activating multiple aspects of innate immunity against bacterial invasion (PMID: 28824166). Both in vitro and in vivo evidence supported that CLEC5A was involved in glioblastoma pathogenesis via regulation of PI3K/Akt pathway (PMID: 30834619). It appeared as a protein band of ~36 kDa because of glycosylation, while its predicted molecular weight is 22 kDa (PMID: 25877931; 19074552).

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