Anticorps Polyclonal de lapin anti-CLEC9A

CLEC9A Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 55451-1-PBS

Synonymes

CD370, C-type lectin domain family 9 member A, DNGR1, UNQ9341, UNQ9341/PRO34046

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Galerie de données de validation

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  IHC staining of human tonsillitis using 55451-1-AP (same clone as 55451-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 55451-1-AP (CLEC9A Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 55451-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 55451-1-AP (same clone as 55451-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 55451-1-AP (CLEC9A Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 55451-1-PBS in a different storage buffer formulation.

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Informations sur le produit

55451-1-PBS cible CLEC9A dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: C-type lectin domain family 9, member A
• Masse moléculaire calculée: 27 kDa
• Numéro d’acquisition GenBank: NM_207345
• Symbole du gène: CLEC9A
• Identification du gène (NCBI): 283420
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CLEC9A (C-type lectin domain family 9 member A), also known as DNGR1, CD370, is a type II membrane protein that contains C-type lectin domain. The C-type lectin domain family members share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. Mouse Clec9A is primarily restricted to dendritic cells (DCs) and selectively expressed in mouse CD8+ conventional DCs (cDCs) and plasmacytoid DCs (pDCs), whereas human CLEC9A is also expressed on human DC subtypes. CLEC9A functions as an activating receptor that recruits Syk kinase and can induce the production of proinflammatory cytokines. (PMID: 25553393; PMID: 15476922; PMID: 18669894; PMID: 18408006)

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