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Anticorps Polyclonal de lapin anti-CLIC2

CLIC2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 14935-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using CLIC2 Polyclonal antibody (14935-1-AP)

    WB analysis using 14935-1-AP (same clone as 14935-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14935-1-AP (CLIC2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14935-1-PBS in a different storage buffer formulation.

Informations sur le produit

14935-1-PBS cible CLIC2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène CLIC2 Protéine recombinante Ag6766
Nom complet chloride intracellular channel 2
Masse moléculaire calculée 28 kDa
Poids moléculaire observé28-30 kDa
Numéro d’acquisition GenBankBC005367
Symbole du gène CLIC2
Identification du gène (NCBI) 1193
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CLIC2 (chloride intracellular channel 2), also known as CLCNL2. It is expected to be located in cytoplasm and membrane. CLIC-2 exists as a monomer. It also has an unusual enzyme activity profile. While the CXXC active site motif is conserved between CLIC-2 and the glutaredoxins, no thiol transferase activity was detected. In contrast, low glutathione peroxidase activity was recorded. CLIC-2 was found to be widely distributed in tissues including heart and skeletal muscle. Functional studies showed that CLIC-2 inhibited cardiac ryanodine receptor Ca2+ release channels in lipid bilayers when added to the cytoplasmic side of the channels and inhibited Ca2+ release from cardiac sarcoplasmic reticulum vesicles. The calculated molecular weight of CLIC2 is 28 kDa.

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