Anticorps Monoclonal anti-CLN3

CLN3 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1E10A9

N° de cat : 67957-1-PBS

Synonymes

Batten disease protein, BATTENIN, BTS, CLN3, JNCL, Protein CLN3

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Galerie de données de validation

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  WB analysis using 67957-1-Ig (same clone as 67957-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67957-1-Ig (CLN3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 67957-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 67957-1-Ig (same clone as 67957-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67957-1-Ig (CLN3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67957-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67957-1-PBS cible CLN3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CLN3 Protéine recombinante Ag31402
• Nom complet: ceroid-lipofuscinosis, neuronal 3
• Masse moléculaire calculée: 438 aa, 48 kDa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: BC002394
• Symbole du gène: CLN3
• Identification du gène (NCBI): 1201
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Neuronal ceroid lipofuscinosis (NCL, or Batten disease) refers to a group of lethal pediatric neurodegenerative diseases originating from mutations in one of the thus far identified 13 CLN genes (Ceroid Lipofuscinosis, Neuronal type; CLN1 to CLN14) (PMID: 25051496). CLN3 is a multi-membrane spanning protein that is involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. The CLN3 gene is located on chromosome 16p12.1and produces three mRNA splicing variants. The 438-amino-acid CLN3 protein has a calculated molecular weight of 48 kDa. It has been reported that CLN3 can be glycosylated and form homodimeric complex (PMID: 10356317; 17286803).

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