Anticorps Recombinant de lapin anti-CLUH

CLUH Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241640C1

N° de cat : 84321-3-PBS

Synonymes

KIAA0664, Protein KIAA0664, FLJ23672, CLU1, 241640C1

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Galerie de données de validation

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  WB analysis using 84321-3-RR (same clone as 84321-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84321-3-RR (CLUH antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84321-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84321-3-RR

  Biolayer interferometry (BLl) kinetic assays of 84321-3-RR against Human CLUH were performed. The affinity constant is below 1 pM.

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Informations sur le produit

84321-3-PBS cible CLUH dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CLUH Protéine recombinante Ag34275
• Nom complet: KIAA0664
• Poids moléculaire observé: 147-150 kDa
• Numéro d’acquisition GenBank: BC156940
• Symbole du gène: CLUH
• Identification du gène (NCBI): 23277
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Clustered mitochondria homolog (CLUH) is a conserved RNA-binding protein, that binds transcripts encoding proteins involved in the respiratory chain, the tricarboxylic acid (TCA) cycle, and other mitochondrial metabolic pathways. Upon loss of CLUH, target mRNAs are subjected to faster decay, and their respective proteins are decreased in abundance. This leads to alterations in mitochondrial distribution (mitochondrial clustering as the gene name alludes to) mitochondrial cristae integrity, respiratory defects, loss of mtDNA, and decreased activity of TCA cycle enzymes. (PMID: 35559794)

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