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Anticorps Recombinant de lapin anti-CLUH

CLUH Recombinant Antibody for IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241640C11

N° de cat : 84321-4-PBS

Synonymes

KIAA0664, Protein KIAA0664, FLJ23672, CLU1, 241640C11

Galerie de données de validation

Filter:
  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using CLUH Recombinant antibody (84321-4-RR)

    IF Staining of HeLa using 84321-4-RR (same clone as 84321-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CLUH antibody (84321-4-RR, Clone: 241640C11 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84321-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84321-4-RR

    Affinity and Kinetic Characterization of 84321-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84321-4-RR against Human CLUH were performed. The affinity constant is 7.19 nM.

Informations sur le produit

84321-4-PBS cible CLUH dans les applications de IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène CLUH Protéine recombinante Ag34275
Nom complet KIAA0664
Numéro d’acquisition GenBankBC156940
Symbole du gène CLUH
Identification du gène (NCBI) 23277
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Clustered mitochondria homolog (CLUH) is a conserved RNA-binding protein, that binds transcripts encoding proteins involved in the respiratory chain, the tricarboxylic acid (TCA) cycle, and other mitochondrial metabolic pathways. Upon loss of CLUH, target mRNAs are subjected to faster decay, and their respective proteins are decreased in abundance. This leads to alterations in mitochondrial distribution (mitochondrial clustering as the gene name alludes to) mitochondrial cristae integrity, respiratory defects, loss of mtDNA, and decreased activity of TCA cycle enzymes. (PMID: 35559794)

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