Anticorps Polyclonal de lapin anti-CMPK2

CMPK2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 25877-1-PBS

Synonymes

EC:2.7.4.14, EC:2.7.4.6, Nucleoside-diphosphate kinase, TYKi, UMP CMPK2

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Galerie de données de validation

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  WB analysis using 25877-1-AP (same clone as 25877-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 25877-1-AP (CMPK2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25877-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung cancer using 25877-1-AP (same clone as 25877-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 25877-1-AP (CMPK2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25877-1-PBS in a different storage buffer formulation.

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Informations sur le produit

25877-1-PBS cible CMPK2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CMPK2 Protéine recombinante Ag22885
• Nom complet: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
• Masse moléculaire calculée: 449 aa, 49 kDa
• Poids moléculaire observé: 55 kDa
• Numéro d’acquisition GenBank: BC141802
• Symbole du gène: CMPK2
• Identification du gène (NCBI): 129607
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CMPK2 belongs to the thymidylate kinase family. CMPK2 may participate in dUTP and dCTP synthesis in mitochondria. It is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy of CMPK2 is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. CMPK2 may be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.

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