Anticorps Polyclonal de lapin anti-CMTM8

CMTM8 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15039-1-PBS

Synonymes

Chemokine-like factor superfamily member 8, CKLF-like MARVEL transmembrane domain-containing protein 8, CKLFSF8

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Galerie de données de validation

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  WB analysis of mouse bladder using 15039-1-AP (same clone as 15039-1-PBS)

  mouse bladder tissue were subjected to SDS PAGE followed by western blot with 15039-1-AP (CMTM8 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse liver using 15039-1-AP (same clone as 15039-1-PBS)

  IP result of anti-CMTM8 (IP:15039-1-AP, 4ug; Detection:15039-1-AP 1:300) with mouse liver tissue lysate 6800ug. This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas using 15039-1-AP (same clone as 15039-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas using 15039-1-AP (CMTM8 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 15039-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15039-1-PBS cible CMTM8 dans les applications de WB, IHC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CMTM8 Protéine recombinante Ag6776
• Nom complet: CKLF-like MARVEL transmembrane domain containing 8
• Masse moléculaire calculée: 20 kDa
• Poids moléculaire observé: 25-28 kDa
• Numéro d’acquisition GenBank: BC041390
• Symbole du gène: CMTM8
• Identification du gène (NCBI): 152189
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CMTM8, also known as CKLFSF8, is a member of the chemokine-like factor superfamily (CKLFSF). Proteins of this family share similarity with both the chemokine and the transmembrane 4 superfamilies. CMTM8 is an attenuator of EGF-induced signaling (PMID: 16263120). Overexpression of CMTM8 accelerates ligand-induced clearance of EGFR from the cell surface and induces apoptosis via caspase-dependent and -independent pathways (PMID: 17149703). An alternative splice form of CMTM8, CMTM8-v2, arises from a deletion of exon 2. CMTM8-v2 maintains the ability to induce apoptosis (PMID: 17681841).

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