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Anticorps Polyclonal de lapin anti-CNGA4

CNGA4 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 22201-1-PBS

Synonymes

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using CNGA4 Polyclonal antibody (22201-1-AP)

    WB analysis using 22201-1-AP (same clone as 22201-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22201-1-AP (CNGA4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22201-1-PBS in a different storage buffer formulation.

Informations sur le produit

22201-1-PBS cible CNGA4 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons rat, souris

Réactivité rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène CNGA4 Protéine recombinante Ag17481
Nom complet cyclic nucleotide gated channel alpha 4
Masse moléculaire calculée 575 aa, 66 kDa
Poids moléculaire observé47-50 kDa, 65-70 kDa
Numéro d’acquisition GenBankBC106936
Symbole du gène CNGA4
Identification du gène (NCBI) 1262
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CNGA4 (cyclic nucleotide gated channel subunit alpha 4), also known as CNG4. It is expected to be located in cell membrane. Cyclic nucleotide-gated (CNG) channels are crucial for visual and olfactory transductions (PMID: 12432397). Native CNG channels are heterotetramers composed of homologous A and B subunits. Olfactory CNG channels are composed of three types of subunits, CNGA2, CNGA4, and CNGB1b (PMID: 15134638). CNGA4 is a modulatory subunit which contributes to the high cAMP sensitivity of the native olfactory channel. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation of native olfactory neurons to odorants (PMID: 11739959; 11739960). The molecular weight of CNGA4 is 65 kDa, and it can recognize the 48 kDa isoform.

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