Anticorps Polyclonal de lapin anti-CNKSR2

CNKSR2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24054-1-PBS

Synonymes

CNK homolog protein 2, CNK2, Connector enhancer of KSR 2, KIAA0902, KSR2

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Galerie de données de validation

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  WB analysis using 24054-1-AP (same clone as 24054-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24054-1-AP (CNKSR2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24054-1-PBS in a different storage buffer formulation.

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  IHC staining of rat liver using 24054-1-AP (same clone as 24054-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat liver tissue slide using 24054-1-AP (CNKSR2 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24054-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24054-1-PBS cible CNKSR2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CNKSR2 Protéine recombinante Ag21183
• Nom complet: connector enhancer of kinase suppressor of Ras 2
• Masse moléculaire calculée: 1034 aa, 118 kDa
• Poids moléculaire observé: 110 kDa, 130 kDa
• Numéro d’acquisition GenBank: BC126121
• Symbole du gène: CNKSR2
• Identification du gène (NCBI): 22866
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purifié par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The Connector Enhancer of Kinase Suppressor of Ras-2 (CNKSR2), also known as CNK2 or MAGUIN, KIAA0902 and KSR2, is a scaffolding molecule that contains functional protein binding domains (PMID: 35053419). CNKSR2 interacts with different molecules, including RAF1, ARHGAP39, and CYTH2, and regulates the Mitogen-Activated Protein Kinase (MAPK) cascade and small GTPase signaling (PMID: 35053419). The study identify a molecular complex comprising CNKSR2 and the guanine nucleotide exchange factor (GEF) for ARF small GTPases, CYTH2, that is necessary for the proper development of granule neurons in the mouse hippocampus (PMID: 34800437). CNKSR2 plays a key role in regulating cell proliferation, and differentiation through multiple receptor tyrosine kinase pathways (PMID: 35053419). The molecular weight of CNKSR2 is mainly 117 kDa (PMID: 29534682). It has also been reported that CNKSR2 immunoblotted signal of about 110 kDa was detected, while a 130 kDa signal was detected (PMID: 34800437).

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