Anticorps Monoclonal anti-CNOT3

CNOT3 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, Lapin, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2E12C6

N° de cat : 68436-1-PBS

Synonymes

CCR4 associated factor 3, CNOT3, KIAA0691, LENG2, NOT3, NOT3H

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Galerie de données de validation

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  WB analysis using 68436-1-Ig (same clone as 68436-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68436-1-Ig (CNOT3 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68436-1-PBS in a different storage buffer formulation.

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Informations sur le produit

68436-1-PBS cible CNOT3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, Lapin, porc, rat, souris

• Réactivité: Humain, Lapin, porc, rat, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CNOT3 Protéine recombinante Ag33646
• Nom complet: CCR4-NOT transcription complex, subunit 3
• Masse moléculaire calculée: 120 kDa
• Poids moléculaire observé: 120 kDa
• Numéro d’acquisition GenBank: BC016474
• Symbole du gène: CNOT3
• Identification du gène (NCBI): 4849
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The CCR4-NOT complex, the major deadenylase in mammalian cells, shortens the mRNA poly(A) tail and leads to the destabilization of mRNAs. The CCR4-NOT complex plays pivotal roles in various physiological functions, including cell apoptosis, proliferation, and metabolism [PMID:22342980]. CNOT3, belongs to the CCR4-NOT complex, has a critical role in maintaining mouse and human ESC identity as a protein complex and inhibit differentiation into the extraembryonic lineages. It is also involved in the regulation of the spindle assembly checkpoint [PMID:22342980,22367759].

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