Anticorps Monoclonal anti-CNTN1

CNTN1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, Lapin, porc

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1C1D4

N° de cat : 68252-1-PBS

Synonymes

CNTN1, contactin 1, F3, Glycoprotein gp135, GP135, Neural cell surface protein F3

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Galerie de données de validation

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  WB analysis using 68252-1-Ig (same clone as 68252-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68252-1-Ig (CNTN1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68252-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 68252-1-Ig (same clone as 68252-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68252-1-Ig (CNTN1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68252-1-PBS in a different storage buffer formulation.

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Informations sur le produit

68252-1-PBS cible CNTN1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, Lapin, porc

• Réactivité: Humain, Lapin, porc
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CNTN1 Protéine recombinante Ag5030
• Nom complet: contactin 1
• Masse moléculaire calculée: 1018 aa, 113 kDa
• Poids moléculaire observé: 130-135 kDa
• Numéro d’acquisition GenBank: BC036569
• Symbole du gène: CNTN1
• Identification du gène (NCBI): 1272
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Contactin-1 (CNTN1), also known as Glycoprotein gp135 or Neural cell surface protein F3, is a neuronal cell adhesion molecule of the immunoglobulin superfamily (PMID: 3049624). It consists of six Ig domains, four fibronectin-like motifs, and a glycosylphosphatidylinositol (GPI)-moiety. Expressed by the central and peripheral neurons, CNTN1 contributes to the formation and function of neuronal connections. It plays a role in axon extension and formation of septate-like junctions between axons and myelinating glial cells (PMID: 23724143). In addition, acting as a ligand for Notch, CNTN1 initiates a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination (PMID: 14567914).

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