Anticorps Polyclonal de lapin anti-Collagen Type XXVI

Collagen Type XXVI Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 21106-1-PBS

Synonymes

COL26A1, EMID2, Collagen alpha 1(XXVI) chain, EMI domain containing 2, EMI6

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Galerie de données de validation

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  IHC staining of human colon using 21106-1-AP (same clone as 21106-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 21106-1-AP (EMID2 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21106-1-PBS in a different storage buffer formulation.

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  IF Staining of U2OS using 21106-1-AP (same clone as 21106-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed U2OS cells using EMID2 antibody (21106-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 21106-1-PBS in a different storage buffer formulation.

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Informations sur le produit

21106-1-PBS cible Collagen Type XXVI dans les applications de IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Collagen Type XXVI Protéine recombinante Ag15382
• Nom complet: EMI domain containing 2
• Masse moléculaire calculée: 441 aa, 45 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC110393
• Symbole du gène: EMID2
• Identification du gène (NCBI): 136227
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

COL26A1(Collagen alpha-1(XXVI) chain), also known as EMID2. It is expected to be located in the cytoplasm and extracellular space. COL26A1 is expressed in many tissues, especially in brain tissues, including cerebral cortex, cerebellum and basal ganglia. In the single cell type, the expression of COL26A1 is mainly concentrated in excitatory and inhibitory neurons. The protein is a new member of the collagen family. Its function has not been fully demonstrated in thyroid cancer (THCA), but it is known that collagen can promote cancer progression. COL26A1 may be involved in immune-related pathways, such as CTLA4 pathway, IL-10 signaling pathway and chemokine receptor binding chemokine. The molecular weight of COL26A1 is 45 kDa. COL26A1 is significantly up-regulated in thyroid carcinoma, and its high expression is related to poor prognosis. It is also significantly related to tumor microenvironment, which may involve immune-related pathways in the process of tumor occurrence(PMID: 38197076).

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